1. Keymod and MLOK are hole patterns. If you want to put on an attachment, you can do it two ways: 1) buy a Keymod-to-picatinny rail. Mount the rail. Then put any attachment that takes picatinny, which is almost universal. 2) buy a direct-mounting Keymod attachment. Mount it directly to the handguard.
Option 2 is preferable, since it’s lighter and cuts out the middleman. Given that MLOK is more popular, you’ll find that direct-mounting may be hard to find. It may be wise to have at least one or two 3” pic rails to start out.
2. Generally, if you’re using a magnified scope, no irons. If you’re using a red dot, get irons. Irons are great because they’ll always be there, never need batteries, etc. I think they are worth it, as a fail safe against anything going wrong with any optic, for any reason, ever.
3. Can’t say for sure, but a cheap soft case will suffice for a long while. It’s hard to crank out $100-300 on a nice case when you could buy something much more important.
4. To change the caliber, you just pop off the upper receiver and replace it with the different one. The AR lower is very versatile, so as long as you have the right mags, bolt, and barrel, most variant calibers will run on a standard lower with no issues.
5. For HD, the answer is usually: optic, light, sling, ammo. A quality budget red dot is ~$100 from several manufacturers. A Streamlight is about $100. A decent sling goes from $30-75. Several spare mags and ammo to go with it (and the rifle zeroed).
6. When you pull it out of the box, it’s a good idea to clean it from tip to butt, checking everything to verify they are correct and in spec. If you find something wonky, you can contact the manufacturer and resolve it ASAP. You’ll also need to zero it, so take the first couple hundred rounds to verify function, break it in, and get your sights dialed in.
7. Nothing really. ARs are adult legos- just plug and play. You can replace bits, upgrade things, swap details. They are pretty robust, and your rifle will probably outlast your grandkids.