The offset will work with even the HLX (which is larger than M600DF or Modlite heads) and with MBUS plastics which are the bulkiest BUIS if you put the head just past the sight sight body and light body next to the BUIS. The only thing I use inlines for is Arisaka head M300/600 lights that are very slim and can even fit the whole head past the MBUS for battery swaps. Never tried a bigger head like an HLX, 600DF, or Modlite with lower profile sights but HLX and Modlite crash into sights and rail on an MCMR with inline mount. For those bigger heads I ALWAYS go Arisaka offset due to the 3 position options. By offset I assume you mean the 45 degree bend MLOK version and not the straight lift/drop intended for use under a DBAL correct? That is too low and wide for optimal weak side thumb operation when run lifting the light on weakside, but fits with a ton of room to spare (really intended for pressure switch from that location IMO).