If you want to shoot heavy subs, you need a fast twist. 1:8 and 1:7 twist for 300Blk are the most common available, and short of a custom twist or a Q barrel, 1:7 is about the fastest of the readily available twists you'll find. If you have any inkling to shoot 210 to 220 grainers, then 1:7. That's all well and good for the heavy subs, but what happens when you shoot 110 grain supers through that fast twist? It's not uncommon for accuracy to go to crap (my 1:7 twist 7.5" 300 won't shoot anything under 150 grain supersonic worth a hoot) because over spinning a bullet causes accuracy issues. Lower twist to get good supersonic light bullet accuracy, then it won't stabilize heavy subs. It's all a trade off.
I'll probably catch flak for this, but IMHO, 300 is best at heavy subs, suppressed in short barrels...it's more or less what is was designed for (since it was spun over from AAC's 300 Whisper). The fact that 308 bullets in lighter weights are available and you can load them in 300 at supersonic speeds is just a byproduct of component availability and parameters. Scaled up to carbine or rifle lengths is where supersonic 300 really "works."
Since you mention home defense, that puts this gun in a completely different category than toy, plinker, fun gun, etc. It means you want to trust your life to it.
My list of criteria for that (and again, I might draw some fire), but this is MY list:
#1 criteria for any defense gun is it must function reliably. The best caliber, the best tacticool toys attached to it, etc don't make a hill of beans if the damn thing won't run reliably. When I hit the bang button, it has to go bang, every time.
#2 The gun must function reliably.
#3 The gun must function reliably.
#4 Tack driving accuracy is not required. Unless you're an NBA player with a mansion the size of your local mall, most home defense encounters are going to be at very close range. There are very few, if any modern firearms that won't hit an intruder across your living room.
#5 If it's adjustable, it has an unknown and unpredictable life span or reliability. Adjustable gas blocks and BCG's are cool and all, but adding them is adding potential failure points.
#6 Whatever you settle on for you home defense arm, practice, practice, practice. The best firearm, the best caliber, the best everything is no good if you can't hit the target.