I have played around with this in various com-bloc calibers with surplus and recent manufacture. I did not find the powder charges to be all that inconsistent. You have to look at more variables than the powder if you are looking to improve accuracy. Weight of the projectile, crimp, etc...
Also the rifle you are shooting the ammunition out of is a huge factor. You can spend all that time and effort to make slightly more accurate ammunition, and not realize the result if the rifle is not capable of being accurate.
In the end, I found the exercise to not be worth the time and effort of pulling the projectiles, re-weighing the powder, sorting projectiles by weight, reassembling and crimping to make 4" group ammunition into 2" group ammunition.
The exercise proved it possible, but not practical.