I wouldn't recommend giving to the United Way, if only because of their policy on the Boy Scouts, plus the fact that they have to use a percentage of what you donate for their own overhead and administrative purposes.
Do you have a local volunteer fire/rescue squad? They generally work on lean budgets, so I'm pretty generous when giving to mine.
My search and rescue team operates on a very tight budget, and it is a charity. We help local law enforcement agencies find lots campers, hikers, hunters, kids, alzheimer's patients, etc.
The Second Amendment Foundation, Gun Owners Foundation, and Friends of NRA are all 501(c)3 charitable pro-RKBA groups. While by law they can't lobby, they spend their money on fighting anti-gun lawsuits and educating the public about firearms ownership.