I you can expect about 3400 to 3500 fps with a 180Gr such as the Barnes TTSX
I would not run any bullets such as Ballistic tips, and even the bonded core type . I have personally seen the Accubonds shed weight and recovered
I have never recovered a Barnes TTSX out of game driven out of 30-378
Needless to say the 30-378 is insanely flat shooting
As far as range goes, its a loaded question....I can easily make hits out to 500 yards but I find that the Accumark just doesn't have the accuracy as my TRG-42 , which is why I now use the TRG ( 338 Lapua ) as my big game rifle for Western Canada hunting . I have personally not shot anything further than 550 yards with it
My go to powders have always been Hodgdon Retumbo and 50 BMG .
Stick with the Norma made Weatherby brass .
I always do load development with the Accubrake but take it off for hunting . Don't care how manley you are .....when you are burning 120 Gr of powder and driving a 180 Gr @ 3500 it will hurt