I typically sight my deer rifles in at +1.5" at 100 yards; that puts POI within 1.5" high or low of POA from 0-225 yards without correction. If the laser says the animal is farther than that, I typically refrain from squeezing.
Typical POA is waiting for a broadside shot at the heart, a liitle high and the lungs get hit, a little forward and the front shoulder bones send massive shrapnel through everything vital.
Although most of the dozen and a half animals over the past few years have dropped where they stood, including a 480# head shot Nilgai cow and a 285# feral hog, some have run for up to 200 yards, even with fatal shots......whitetails are extremely robust survivors.
Nosler Partitions are very good at terminal ballistics for thin skinned game; maybe one day I'll actually recover a projectile.