Locktite is a good idea. If your concerned with dripping, here's what you do:
Disassemble the gun, remove the trigger assmbly, bolt stop pin (at the rear of the receiver), remove the bolt and handle/spring assembly (slide it all the way back and wiggle it out)
You should now have an empty receiver.
Screw the scope base on using locktite. Wipe out any excess that comes into the receiver.
Wait an hour or so for the locktite to set.
Check to make sure there is no locktite inside the receiver.
YOu could use this opportunity to thouroughly clean the bolt and receiver.
Reassemble the rifle and mount your scope.
Enjoy.
Also, since you have it taken apart, you might wanna replace the bolt stop pin with a plasic buffer. Mine is from BufferTech. It nearly eliminates the slam of the bolt when it cycles, and should prolong the life of the receiver (old 10/22's are known to have the holes deformed from the hammering the pin gets from the bolt. It also will reduce cycling noise in suppressed applications.