I have one of the first ones, a 4" 22A.
At around 35,000 rounds the firing pin broke, it broke twice since then.
Around 55,000 the hook at the end of the sight rib broke, S&W sent me also that under warranty and I put it on. I noticed that they changed the design of the hook.
At a little over 60,000 the frame broke right above the trigger, S&W sent a UPS label and built a new frame with my serial number and returned it within three weeks.
At that time they also changed the recoil spring and the main spring, too. The main spring had become about a quarter of an inch shorter.
I still use the original magazines and changed the plastic recoil buffer three times, the original one lasted most of the pistols life, the new ones are going faster.
***Edited to add, the sight rib came loose several times and I finally used blue Loctite for that and the barrel stud to stop it from walking out.
All I use to clean this gun is WD40 - just because so many internet jockeys bash it. About once a year I detail strip it and clean it thoroughly.
Yesterday one of the mags had a feeding issue that seems to be gone after cleaning the mag, I will find out next time at the range.