+1 on the Glock 20. This solves the "caliber question" once and for all... 10mm is an extremely effective defensive pistol round. As you probably already know, .40 is nothing more than a "downloaded" 10mm and it retains most of the effectiveness of the full power 10mm. Research doesn't really show that .40/.45 caliber bullets are that much more effective than modern 9mm JHP bullets. Realisticly, a Glock 17 loaded with 124grn +P Gold Dots will offer you the same/similar level of protection/lethality as a G22 or G21. I tell people to select a handgun/caliber that best suites them and thier understanding of terminal ballistics. Some gravitiate towards light/fast and some prefer slow/heavy. I prefer 124 and 147grn 9mm JHP's for my Beretta M9, more over I use the BH 124grn +P Gold Dots as my carry load. I reguard the
Beretta M9 as one of the foremost "wonder 9's" and one of the best combat handguns. That being said, I despise the Beretta M96, as its vastly inferior to the G22. 15 rounds in the G22 is hard to beat and for a .40 S&W handgun, its tough to beat. I also really like the G17 as it too is an excellent weapon, though I prefer the M9 or Sig 226. 9mm JHP's provide excellent terminal ballistics and an excellent level of protection. If you are forced to use your handgun in an armed confrontation, you are more likely than not to have to shoot multiple rounds. That being said, you will want a weapon with high capacity and low recoil, which describes the M9/G17/226. It comes down to personal preference in the end as both a G22 and G17 will be equally effective in real life deadly force confrontations. I prefer a 9mm because of low recoil and high capacity, not to mention typically smaller/lighter weapons*excluding the Beretta M9*. Knowing I will more than likely have to shoot an attacker multiple times to stop the hostility, I want plenty of rounds that are going to be as potent as possible. Both the G17/G22 are excellent defensive weapons and which you should use should be a function of your level of skill/familiarization and personal preference. A G17 with 147grn Rangers or a G22 with Federal HST's are both excellent choices.