You don't.
Revolvers are simple looking actions that are more complicated then they appear.
Samuel Colt was a true Yankee machine inventor. When he started building his first revolvers, he had to invent the machinery that could do the complex machine operations needed.
Colt and his mechanics were forced to invent modern barrel boring and rifling equipment and modern lathes and milling machines just to make the "simple" black powder guns of the day.
Without a good lathe and milling machine and some high-end machinist skills you'll find actually making a gun from scratch is not going to work out.
In order to get a cylinder that will index requires surprisingly high precision equipment that a drill press is simply unable to do.
Among other operations, the chamber holes must be high precision bored in perfect alignment and the locking notches and the ratchet on the rear have to be very precisely located or the gun will be firing with chambers not aligned with the barrel.
There's no way a drill press can machine the ratchet, and its not precise enough to bore the chambers correctly.
The second part of cylinder rotation is the frame, hammer and "hand" that actually pushes the cylinder around to the next chamber. The frame is a complex part that requires the ability to machine-broach square holes for the hand and hammer, the hammer and hand construction are way beyond a drill press.
I suggest buying a cheap, used black powder revolver, disassemble it and look at the required machine work needed to build it.
My advice: Either buy a BP revolver, or if you just want to do this as a project, buy a BP revolver semi-finished kit and assemble it.
I'm a retired Master watchmaker/Colt double action revolver gunsmith. Even with my high-order hand work and filing skills I couldn't do it with just a drill press and come up with something that would be safe to fire or even work correctly.