i load for my glock 35 (40 s&w). so far, no problems.
the brass is definitely glocked (i load middle of the road - around 1300 f/s w/ 150's), but after a run thru the sizer, all is well.
as far as defense... since i learned to handload, the only failures i ever had was w/ commercial ammo. most recently, the same glock 35 choked on factory hardball. i guarantee you that if i am carrying the gun is loaded w/ jhp handloads.
i don't understand the mindset of carrying somebody else's loads... you wouldn't shoot a box of ammo that i rolled myself and handed you - so why would you do that w/ something somebdy else loaded? load your own, and you are in full control of the quality; everything from velocity to accuracy. the factories can (and do) screw up. i don't trust factory loads. i do trust my own handloads... also, when you handload, your brass tends to gather in one little pile, instead of being scattered all over the range - which really is nice. get a chronograph sometime, and run the factory loads over it. you will find out that your gun is not performing anywhere close to as well as you hoped it would, and not nearly as well as you thought it was...
anyway, loading for a glock is no big deal.