I'm assuming that you're using the rifle in self defense within your house. The longest range available in my house is about 40 feet shooting from my bedroom's balcony area across my "great room". At ranges like this I can hit the center of mass without sights at all.
If I'm shooting the length of my property - about 150 feet I would like a pair of sights. Irons work and a red dot of death is great.
I use a .357 magnum revolver for my house defense weapon. The ability to use the other hand to open doors, hold a cell phone, or a flashlight is great. It wears a pair of Crimson Trace grips and they're very good for indoor use. They allow me to keep a steady hold on a target without my "full" attention.
I live in a single family home with nice thick walls, double pain windows, nice locks, ample lighting, high fences and in a neighborhood full of retired cops and corrections officers and large noisy dogs. I don't think I'm going to need an M-60 to fend off the hoards of swarming armed gang members.
My M-4 with a Comp ML is a wicked tool of death. The dot is so fast and accurate that I have full confidence in my abilities to put hot fast lead on any target at any reasonable distance. The rifle is the tool, the sight just an aid ... it's the man behind that tool that does the "work".
It's a zen thing for me. Part of my Buddhist training - we practice the most deadly martial art - and becoming one with the weapon comes with time and practice.