I noticed several messages on .223 deer loadswhen I was last paging through the board. Just a quick note from my experience FWIW...
Several years ago, I bought a Remington 700 in .223 very cheap. A fellow had built up a rifle around a used action, using a 26" medium weight shilen barrel with a relatively cheap stock. He "couldn't get it to shoot straight" and I picked it up for about the price of a decent action. Anyhow, I was fortunate enough to know someone who could properly bed the action and barrel; that, plus a truing-up of the action and a proper barrel break-in, and it was shooting up a storm.
Anyhow, last year I had the chance to do some hunting in Texas with one of my father's friends, and the only rifle I had in useful shape was this one. Problem: 1 in 12" twist. While it shot brilliantly with lighter bullets, the 64 gr PP (which I understand to be quite a good deer round) turned in a sloppy 2.5-3 MOA, which was 5-6 times what the rifle could do. (Not Winchester's fault, of course -- just not stable enough.) A friend suggested Barnes bullets, so I bought 100 of the 53 gr XLC (NOT cheap), and pumped it up as hot as it would go from this barrel. My understanding is that rifles can be quite finicky with the Barnes slugs (especially the coated ones), but this one was right in the groove, averaging just under 0.6 MOA.
I took two deer under my tags and two more under tags of others in the party. While 4 animals certainly doesn't make a statistical data base, I can say without a doubt the bullets performed very well for me.
All kills were one shot to the pericardial volume, with no animal moving more than 25 yds; one fell right over. Ranges were from about 70 to just under 150 yards. I recovered two of the four bullets, with both of them pretty much intact and peeled back in the intended "x-bullet" shape (one petal missing from both). The bullet path was not what I was used to in a lightweight .223: deep penetration, and a consistent ~0.5-1 inch channel just plain chewed out.
Under the circumstances (stand shooting with a solid hold, extremely accurate rifle, good conditions, stationary game, etc.), I suppose you could have done the same with a 22 Magnum. Just the same, the perfromance of the bullet bespoke a potential to do well even under less-than-ideal conditions, if you are stuck using something lighter than what you might otherwise prefer.
(Note -- I'm not related to or otherwise involved in any way with the Barnes people. Their product worked really well for me.)