.300 or 5.56? You can shoot 3X the ammo with 5.56, it's that much cheaper. Unless you have some specific ballistic reason to go big on the bullet and payload it's going to cost more to shoot it.
The more you shoot, the better you are, the better shot placement is, the less you need to bandaid downrange effects with a bigger bullet. 5.56 from a 10.5 is plenty fast and you can get 77 gr bullets if you need more impact. Even so, 5.56 out of a 10.5 is still plenty good for deer hunting under 125 yards - which is the majority of shots in broken edge and woodland. Or as a PDW in almost any situation.
.300 is the cartridge of the month, sure. It's not 3X better for the cost of the ammo. Not even. That's what the 6.5 and 6.8 shooters have discovered, and I'm still waiting for $12 a box plinker ammo for my 6.8. $8 a box 5.56 is there now.
Just one point of view. I'm building a 5.56.