In My openion, the 450 Bushmaster is somewhat ill-conceived. It's got the wrong twist in it, so it limits the gun to pistol bullets. A 250 grain 45 cal bullet at 2000+ FPS is good, but not in the league of a 400 grain 45 caliber bullet at 1600 + fps.
We try to re-invent the wheel yet again.
In 1876 Winchester brought out the M-75 and on shell it was chambered for was the 45-75. The 45-70 Government had been out for 3 years. In 1881 Marlin brought out the M-81 lever action and in 1886 Winchester brought out the M-86. Both the M-81 Marlin and the M-86 Winchester would use the 47-70, and hunters that killed bigger game then deer were usually more fond of the 45-70. See, the 45-70 shot 405 and 500 grain bullets at 1200+ FPS and the 45-75 shot 350 grain bullets at 1400+ Fps.
Both were effective and popular, but it was the government round that won the contest of popularity, and was by far the favorite for buffalo, bear and elk.
Now it's somewhat similar to today's 458 SOCOM and the 450 Bushmaster. The Bushmaster is OK, but I don't think it's going to have near the uses of the 458 SOCOM. The SOCOM can be used to deer and hogs, but also for moose and Grizzlies and everything else too.
Why Bushmaster just had to change the formula is beyond me. I guess it's the old story of the Emperor's New Cloths. Someone at Bushmaster just "had to know something special" and try to defy the laws of physics again, and make everyone thing it's was something special, but 130 years of hunting experience of American hunters may contradict them.