Newbe,
I'll throw some numbers out at you, to help visualize what is going on.
First, the trajectory is mostly a function of bullet speed and ballistic coefficient. Using the 300 Barnes X spire point, the bullet that Marty designed around originally, here's what things look like.
At 2000 fps muzzle velocity with a 100 yard zero and a 1.5 inch scope height:
(these numbers are rounded, roughly, and I can easily get 2000 fps with my 20" bbl)
100 yds - 0.00
200 yds - down 10 inches
300 yds - down 32 inches
400 yds - down 74 inches
500 yds - down 137 inches
The kicker with this bullet is that at 200 yards, the velocity is at 1600 fps, which is the lower threshold of the bullet to open reliably. No expansion equals FMJ performance with this bullet. And, if you run the numbers with any of the flat point bullets designed for the 45-70 lever guns, it gets real ugly, fast.
You can use the numbers to roughly calculate the number of clicks needed, and it is easy to see that you can easily run out of scope click adjustment pretty easily past 200 yards. You can use similar math to help decide the number and spacing of crosshair ranging marks might be useful. It is also worth noting that a 30 mm scope tube will have more available clicks than a 1 inch tube.
I guess the bottom line in deciding what to do for a reticle and/or scope type is to figure out how far you want to shoot accurately, decide on a bullet, run the numbers through a ballistic program, then compare the drop numbers to what you want to have to do in the field. One minute of prairie dog or piggie is not the same as one minute of elk. Then there is always the option of spending the money on good clear glass with a simple cross hair, and using good old Kentucky elevation.
If you want me to run any numbers specifically for you, or clarify what I have posted, drop me a line.
Craig