Vepr,
I will add to what Marty posted.
One poorly understood phenomenon in internal ballistics is the theory about the powder column, the plug buring effect on the column and other such detail that is way over my head. I have talked with the gentleman who has written extensively on the subjet. Basically what can happen in a round is that the primer force can actually start the column of powder and bullet moving before ignition starts. His testing is done primarily to address neck tension and crimp, shoulder design and their importance. It might seem to me that radically compressing the charge could affect the burn characteristics of the powder by reducing air space and as Marty pointed, crushing the powder. If this would indeed affect the burn rate, you could get the whole mass moving enough to force the bullet closer or into the lands just slightly before ignition. This could send pressure through the ceiling, and parts into the air. With that being said, I like a little compression in an autoloader, as this can help with preventing bullet setback upon feeding.
One thing that I know to be completely true is that any deviation from published pressure data, be it the primer, the case, the crimp or the bullet will affect the pressure in some mannor. I know of a lot of folks who routinely mix parts from the reloading books, without starting the load workup sequence over. This is usually not a serious problem as there is a bit of "room" built into the entire pressure system, but it could be. I cannot fathom a situation where high compression would lead to the round going off in your press unless you were doing something so off as to crush the primer in some method.
Craig