I've got little input as to the 45 wheel gun. Ruger makes a convertible single action 45 colt with 45 ACP cylinder. I don't know of much else, but that means little.
As to a bolt gun: In my mind, my hunting firearms and my longer range shooting firearms tend to be different animals. Most times, I want short, light, easy to carry hunting firearms. Despite owning more than a dozen different hunting rifles, the one rifle that gets used the most - by a VERY large margin - is now 25 year old Rem Seven in 308. It wears an original Leupold VariX III 1.75-6x scope. This little package is the same length and weight as the much vaunted 'champion' of woods guns, the Win 94 30-30, but packs 308 punch, and by virtue of the scope has far greater useable range. However, a long distance rifle this is not. Its too short (velocity losses), too light (moves to much), and wears a low power variable.
For longer range shooting, I use a Tikka CTR, 20", in 6.5 Creed with a Leupold VX6 2-12x. Scarily accurate and a pleasure to shoot. This rifle is far more accurate, and far easier to shoot accurately, than the Seven. However, this is not a light rifle. It feels like a howitzer compared to carrying the Seven. Completely adequate for hunting from fixed blinds. But carry all day woods cruising? Too damned heavy....
I'm a huge fan of light portable rifles. But it comes at a price: Light portable rifles, those easy to carry all day, tend to be really hard to shoot really well. Its sort of like the usual CCW compromise: Do I pack a really light easy to carry firearm like a Ruger LCP? Or do I opt for the full-sized, heavier, more powerful handgun like the full-sized 1911? Those tradeoffs always involve compromise...
Value for money, with decent handling characteristics and accuracy, look hard at some variant of Tikka T3x....