I have owned almost all of the big bore pistols commercially available, and those that I did not personally own, I shot quite a bit any way. Here is the list that I have shot extensively.
LAR Grizzly 45 Win Mag, 50 AE, 10mm, 357 Mag, 357/45Win Mag
Desert Eagle 44 Mag, 357 Mag
TDE AutoMag, 44 AutoMag, 41 Jurras Mag, 357 AutoMag, 30 Lomont Mag
Coonan 357 Magnum
Wildey 45 Win Mag
AMT AutoMag V 50AE
Out of all of these, the AutoMag V is the worst followed closely by the Wildey. The DE is not bad, but overly large and mine had a terrible trigger and jammed all the time. My all time favorite is the original AutoMag in 41 JMP, but it is not 100% reliable all the time. So when the chips are down, I'll take the LAR Grizzly in 50AE any day of the week. Its my choice, hands down, and I happen to have some personal experience with these types of guns.