Yes. Rear fixed sights are adjustable left to right, and even a millimeter can make a 5 inch difference at 25 yards. Once sighted in, either a screw is tightened and loctited, or just loctite is applied, locking them in place.
Front fixed sights come in varying heights, to adjust the point of aim.
I have one G-19 that needed .180 height front sights, as my .165 standard ones resulted in shot groups 3" high at 25 yards.
That said, all the people who say most gun fights happen at less than 10 feet will chime in. That's true if all you plan to do is shoot it out in an elevator, but if you want to plink soda bottles or varmints at 15-20 yards, your sights may need adjustment to hit properly.
You can sight them in yourself, but rear sights in particular take alot of effort to get into the slot without cosmetic damage. Sometimes it's better to pay someone who's done it a bunch of times, and has the tool to do it, do the work.