JP,,,, don't do it.
There's so many reasons, that I don't know where to start.
I've used 357 for brown bear before, & every time I think "Never again" (If for no other reason - it's inhumane).You're right about the power of the 41, with the right loads it's right up there with a 44... & that's just another reason to go with 44.
If it's going to kick like a 44 mag - you may as well have the benefits of a 44 mag - which are many. The two biggest reasons are the cost of the (harder to find) 41 ammo, & the sheer number of choices you have in 44 loads - especially if you don't reload. Even if you do reload, 44 cases are twenty times more abundant, & a lot of the "serious bear pills" (Barnes, etc) are listed but mysteriously scarce in 41 (Yet plentiful in 44).
I don't mean to take anything from the 41 - it's a serious caliber. I just mean that even using "The most powerful handgun in the world" (Yeah, I know - It wasn't true then either) is a distant 2nd to using a real gun (read: Rifle) to start with.
I also agree with tc6969, Taurus has to be nuts to make a TI 41 mag - you [u]will not[/u] like what happens when you pull the trigger on that thing! If you're a 275 pound monster made out of pure muscle - you'll just make a better platform for this little "bruise machine".
If you're set on it, you'd better try that thing first! That "extra" weight in a Red/Blackhawk, S&W 29/629 feels realy good when the primer gets hit.
[i]About the "The most powerful handgun in the world" thing - I'd swear it seems like bears don't read, & they don't go to movies.[/i]