It's all relative to the size and location of the puncture, as with all sealants. I have yet to see that stuff stabilize for any length of time, and when we get a tire in the shop with a leak -which happens several times a day- the sealers are always broken down to liquid. We had a few of them explode on the hwy, the extra rotating mass of the sealant is a negative side effect. Slime is really no different than other sealers, and none of them are good for everyday driving.
Once a puncture is had, the tire may or may not be sealed, but in any case it will be low on air and the heat buildup may lead to a catastrophic failure. I've seen this on more than few of our customers cars, thankfully none were hurt.
Quads and dirt bikes that go out deep into the bush(or desert) would be the only real use for Slime.
A 4x4 truck/jeep etc should never go into the bush without a spare, air tank, and some tools.
Please use Slime and other tire sealants with due caution, use for emergency only!!