The big advantage is a longer barrel in a shorter overall length weapon. In .223 this can be very helpful when you're trying to keep the velocity high enough to properly fragment at longer ranges.
The biggest drawback IMHO is the placement of the mag. Its always somewhere back under your face, making mag changes awkward and slow. Additionally, in most cases, you've got to break your cheek weld and sight picture to do it. That is, with a conventional rifle, say an AR, you can do a tactical mag change, keep one round in the chamber while you swap mags, and keep your target covered at all times. Granted, it won't be as steady with your left changing mags and not holding the gun down, but you still can have them in your sights and put one round on the target if need be during the middle of a mag change. With a bullpup, its possible, but difficult and awkward at best.
The right hand ejection on a bullpup also has a tendency to interfere with the shooter. Just remember, the ejection port is very close (usually just inches below) to your face. For lefties, its almost impossible to use, for righties, you'll probably still experience a bit more smoke and noise than with a conventional rifle. If you're right handed and have to switch to left to shoot around a corner, you've got a bit of a problem.