Sure, it can be done, how easily depends on the motor. Modern engines that are still using electronic distributors are simple, but points were always a weak link in hi performanc applications. I went to electronic ignitions in all my GTO's and other GM's back in the day.
Many blocks today are using DIS ignitions, to eliminate them would require a distributor. Good thing is that some of these blocks USED to run distributors at one time, for example the 2.8, 3.1, 3.3, 3.4 etc GM motor still has a distributor hole. It's just blocked with an 'O-ringed' base so it doesn't leak oil, which doesn't work well as they still leak all the time, and they have gears to drive the oil pump off the cam. Fords 3.8L also has a distributor hole on some blocks, only they put a cam sensor driven by the cam gears in place of the distributor. These blocks, and others like them, can easily be converted to a distributor if you like. A number of the V8's are basically the same blocks that rn distributors so they can be changed too.
Fuel may be a little trickier, going to a carb would require a new intake manifold, probably a custom job unless we are looking at one of those V-8's where carb ready intakes are available at a reasonable price.