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OK, Rigby wins.
But for everything short of a rogue bull elephant, would the .45/70 be an acceptable choice?
ETA - at relatively short range, of course.
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45-70 is a hammer up close, but Idk that it has the penetration for the really, really large game animals like an elephant, rhino, hippo, etc. A 375 H&H is even considered a bit on the small side for those animals (although with a good bullet it can take any of them), and that round is no slouch. From what I've read anything .40 caliber and above (in regards to "safari rounds") should have no issue taking anything on Earth. The only round in that group that may not be up to it is the 450/400 Nitro Express.
I think the 45-70 is best served as a defensive weapon for bear and moose. If I was hiking or w/e in grizzly country, I'd take the 45-70 with Garret rounds over the Rigby. The Rigby has way more power, but as funny as it sounds it's really overkill for anything in North America, even the largest bears. Plus you can get faster follow-up shots off with the 45-70 lever action, and to add to that any defensive situations where you'd need would probably be well within the range of it's capability. Now if I was actually hunting a bear or moose, I'd take the Rigby because you get all the power with the ability to take much longer shots than you could with the 45-70.