Now, ultimately, this is YOUR gun. Get the one you really dig. If you like the new Ruger MK IV, 22/45 Lite, get it! Spend some on the trigger and enjoy a great gun. Or, hunt a while for a threaded Buckmark. You don't have to spend much on them, but they are much harder to find. The Buckmark does not require disassembly to scrub it down well. The new MK IV is super easy to break down and clean.
Both can be turned into awesome guns for a person who knows what they want. If you are a Ruger MK series guy, stick to that platform. If not, go try out a Buckmark.
Suppressed? Maybe the open design of the Buckmark might be a slight advantage... maybe.
One other thing to note. The Ruger MK series is ... unique. The upper receiver, the barreled portion is the serial numbered gun. Replacing barrels is another 4473. Such is not the case with the Buckmark. Barrel replacement with the Buckmark is simple and straightforward.
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