I've tried like 5 RMRs, 1 DPP, and 1 trijicon early model red dot (similar to the BURRIS FF).
The clearest red dots that I know are reliable, like Deltapoint Pros, have questionable battery life.
I think RMRs are probably getting to be 100% reliable (my RM01 was), but the tiny window and tiny and magnification/distortion make close-up transitions slower than irons for me.
I have only put 2000rds through with MRDSs, but even though it's fun to shoot them at 10-25Y, I they slow me down on the timer at the most likely ranges of 3-5 yards. But that's just one target (though the group is smaller) OR with one or two transitions as well. IF they had a "tube" it would be fast to "tube shoot", by the open ones aren't good at that.
I think soon we'll see guns made with a non-reciprocating mid-and-front section that allows mounting of MRDSs.