My wife is a lefty. I plan on getting her a grand power.

ETA grand power p11 is fully ambi

H&K P7M8 or M13. Best handgun you will find in 9mm. They stopped making them so they're a lot more expensive as are the magazines. But, they're super reliable, ambidexterous, and super fast for combat reloads. The magazine release is located on both sides of the frame beside the trigger for right or left hand usage. The slide release is the grip. Squeeze the grip to release the slide. Many people think the design is too weird for them and looks difficult to master. That is far from true. I used to think the same mistaken things until I actually went and picked one up and played with it for a few minutes and then I discovered the "genius" of the P7 M series design.