If you take apart a Hi Point, you'll see that there is only a "lollipop" of metal (unknown composition) that slides in a race in the slide. That "lollipop" holds in the striker mechanism and is held in itself by a roll pin, which is surrounded only by the soft plastic that they use. That and the barrel port surrounding the barrel are the only two things holding the slide onto the frame.
I have a JHP that I have fired several boxes of warmer loads that began to stretch the frame where the roll pin holds in the "lollipop", not to mention chattering in the striker channel from the slide starting to lift. It began to have firing issues (offset primer strikes) and other issues before I gave up. That was just warm .45ACP, not +p and all loads well within box max. I would not trust the Hi Point design to take much more abuse than what it was designed for.
That being said: I've had a C9 for about 10 years now that I've run about 3k rounds through with minimal issues, other than the bore being worn very smooth and subsequent accuracy issues. It has been a trooper and has not subjected itself to inordinate wear (I actually take my HP down and clean them, this act usually separates the "it's junk" from the "no issues" HP guns). I like it and actually keep it in the garage in case of any driveway issues, lol. It's not my first tier of defense, but I would trust it if I had to.
And yes, I've seen videos of people shooting .45 Super and reaming to Rowland online. I shot about 20 rounds of .45 Super out of my JHP but had frequent jamming issues (overstripping magazine capability of feeding) and the bolt face appearing very well worn after even just 15 of the rounds.
I suppose you can do it but just review the actual design of the weapon and think about what you're holding: You're holding a piece of weapon designed for the lowest bidder, worst than government situations. They offer a lifetime, no questions warranty on a gun that expensive is a flag, not a feature. I like my Hi Points, I like screwing around with them, but if it does go up, I think HP will replace the arm, but maybe not function of your fingers.
Nothing wrong with one that runs, but to go outside of parameters seems like a really bad idea.