My favorite load when I carried a model 66 back in the 70's and 80's was Winchester 145 grain Silvertip 357 Magnum. The 145 grain Silvertip used flash retardent powder and the jacket went into the nose like semi auto pistol bullets. The 145 grain Silvertip penetrated glass and steel car doors better than the lead nose jacket hollow point bullets. There was a significant difference in muzzle flash shooting the 125 grain JHC 357 WW, RP or FC compared to the 145 grain Silvertip. Recovery time with the Silvertip was the same or quicker than the hot 357 125 grain defense loads which were common in the 70's and 80's. The deer I shot with the Silvertip were dispatched just as quickly has those I shot with the 125 grain JHP 357's.
If you can't or don't want to tolerate the magnum loads I prefer the 158 grain lead hollow point +P 38 Special "aka" FBI load. My agency used to qualify with 148 grain HBWC or 150 grain lead SWC 38 Specials then it was the Officer's choice on duty load since the Department vary rarely provided duty ammunition. This was a small department and when I was hired they gave me a mix of different 38 Special cartridges. The Department never gave me another cartridge for duty use but required me to turn in 18 rounds when I left eleven years later. Fortunately many agencies provide better equipment and training than they did back then.
Regardless the model 66 is a fine revolver but was replaced in LE with the L Frame 586/581 - 686/681 for Agencies which shot continually with magnum ammo.