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For real life and death 500 rounds with ZERO issues of ANY kind and decent performance on target.
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500 rounds of carry ammunition? If so that's ludicrous...
You realize that LE agencies around the country (with a much higher likelihood of actually having to use their sidearm) don't even do that.
My agency when adopting a new service pistol purchases several cases of the proposed ammunition and several sample pistols for testing. Once the handgun and ammunition selection proves reliable, the guns and ammunition is purchased in volume and is issued to officers. The qualification is done with nothing but FMJ (Speer Lawman), and duty ammunition is loaded without ever firing a round of it through the individual issued pistol.
The fact is, if you are carrying a big name defensive auto (Glock, M&P, P320, etc.) it's going to work just fine with modern defensive loads.