I think #1 gets it.

Capacity, vs. recoil, vs follow up shots all matter in a defensive handgun.

In hunting, you have all the time in the world compared to a defensive situation. If you don't get a deer because your first shot with the .357 handgun misses and you don't get a second. No one cares. Just wait to the next one.

Hell, its why some guys choose to shoot deer with TC contenders in 30-06. Because they have ample time to fuck around making one powerful hit with a less than practical firearm.

Its why people hunt deer with black powder and bows. Both perfectly capable of killing an animal in one hit, in many cases more effectively than a defensive handgun round. Its just that those weapons are not good choices at all for personal defense against possibly armed humans, since one shot kills are not the only variable.

Shooting an animal with a caliber that has enough ass to pass through consistantly sure makes tracking a lot easier.