I was thinking of picking up some more frangible handgun ammo, in case I decide to do any plate shooting or indoor shooting at my regular, old, short 50ft. range.  One reason is less chance of splash back, and one is the lead free primer.  Otherwise I would use regular fmj ammo, as it's usually significantly cheaper.
I was especially looking at the stuff loaded with the Sinterfire brand bullet.  After looking at their promo video, where they have to tumble the bullets before they are sold/loaded, because of "caking" on the outside of the bullet, I wonder if there is any hard evidence that this can accelerate barrel wear.

I believe there are different ways of getting the all copper/tin bullet compressed together.  I believe some even use a polymer, that when heated, binds the copper particles, with others doing it differently.  I think in the past, when I researched some from the Remington line, some had a jacket around the particles, and some did not.  I wonder if this makes any difference?

Just wondering if anyone has had any extensive experience, as I haven't shot a lot of frangible stuff in the past.

I believe the lead-free primers you mentioned are particularly hard on barrels, but I can't speak to the frangible bullets themselves.

Not a concern at all. You need to shoot tens of thousands of them ( who could afford that!) to have any effect at all if any. You may also consider cast lead as they tend to flatten easily and provide much less chance of splash back as well.