From what I've seen, it's tissue damage/bleeding out that is the big killer compared with the central nervous system. The center of mass usually correlates with the heart, lungs, liver, bowel, large abdominal vessels that don't have as much bony protection. Nature tries to armor the CNS by putting bones around it, making more practical in most cases to punch enough large holes in someone to bleed out. The brain is encased by the bony skull. The spinal cord? Shooting from the front, you have an inch or two of bone to penetrate before hitting the cord AFTER passing through the soft tissue in front, and that's assuming you even hit it. It's hard enough to put an epidural in from the back if someone's moving around in labor. I'd not stake my life on punching the spinal cord of someone attacking me from the front.
Precision head shots are useful, but hard to take reliably under stress for the average shooter, especially if that head is moving/bobbing/weaving while the shooter is also moving/bobbing/weaving, shaking & scared to death. Either way, I agree with the main principle in FALARAK's post - the goal is to have a projectile that does damage, but shot placement with some useful knowledge of anatomy is key. Bleed someone out enough, and they'll go into shock - stopping whatever it was they did.
FALARAK's line bears repeating: skills, training, and shot placement will likely have a much greater effect on whether you survive the encounter than bullet construction. I've seen lots of folks die from unexpanded FMJs in the right place.