If you’re talking about JUST the upper receiver itself, it’s a different question from if you’re talking about complete, barreled uppers.
If you stick with a well known brand, it’s hard to beat a forged (stripped) upper. They are mechanically stronger, not just because of the stronger alloy used in most forgings, but because of the forging process itself.
Forging into the rough shape of the upper builds in strength in the critical areas such as the front, threaded part of the upper. If you’re planning to build an upper with a long, heavy profile barrel, I think you will see a difference in the stiffness of a forged upper compared to the typical billet upper.
To me, billet uppers and lowers can provide a few features that aren’t usually available in forged receivers. My Glock-specific lower from Quarter Circle 10 is billet because of the changes they needed to make in the magazine well area to accommodate Glock magazines.
On the other hand, I see a lot of billet parts, mostly lowers, that seem to be an opportunity to “express the artistic side” of the maker. To me (PERSONAL OPINION), skulls, flames and shark teeth belong on motorcycle tanks, not ARs.
If, on the other hand, you’re talking about complete, barreled uppers, YES there are differences between makers, their level of experience and attention to detail, and the parts they choose. I have bought only a few complete uppers, and only after thoroughly researching the manufacturer of each, because I have built enough uppers to know how easy it is to goof - or to cheap out.