Got nothing against going to Mars, I just dont like trying another manned cannonball shot like the Apollos were.
We need to have a spaceship first, one that you can actually fly and isn't a prisoner of Newtonian Physics and can abort or divert if it has problems, is large enough to repair itself. Better yet build two so one could go and rescue the other if things really got cocked up.
It would still be the outer space equivilant of a carrack, but it would be a safer way to do it than trying to piece togeather some girders and tin cans, and slingshoting them out into space on the shortest Hohmann orbit, which will still get the crew microwaved for 11 months each way and stranded for another 12... no thanks thats just asking for trouble.
Develop the Moon first. Build foundries there. Build a true space ship, nuclear powered, about the size of a [i]Ohio[/i]-class SSBN. A couple inches of Ti or HY80 steel will keep out all the nasty rays and micrometeoroids much better than 2gm/cm2 standard aluminum shielding they got on the ISS. Also make nice containment for a real nuclear reactor rather than wimpy solar panels and batteries. Assemble it in Lunar orbit, you'd have to since there no way we could afford to launch something that massive entirely from the Earth.