FWIW, I am very happy with the 22/45. It is lighter, and while I haven't had a chance to wring out the 22/45 for accuracy yet, it hammers clay pigeons pretty easily up to 50 feet, even with the rudimentary sights that come with the thin contour barrel. No jams yet either.
I don't really see why the 22/45 ought to be markedly less accurate, unless the feeding pattern is different than the MkII. The top ends are pretty much the same right?
My stainless MkII actually DID have jamming problems, which caused me considerable irritation.
I don't think that all stainless ruger pistols are like this though.
One of my friends who unlike me is actually a legitimate shooter had the idea that Ruger QC was a little looser than other manufacturers for many of their products. Looking at the finishes and some of the inelegant lines, I would kind of agree, but have no proof that ruger QC is lower.
For a tough, inexpensive 22 autoloader, ruger has yet to be exceeded.