I wouldn't say that I came remotely close to hiking the entire Appalacian Trail, but I have done bits and pieces of it in North Carolina. We tried using cell phones, just as a safety precaution and had very little luck. The FRS radios were great to keep touch with each other when we got separated by more than a few hundred yards. From my time on the trail, the following MUST BE ADDRESSED:
1 Don't go alone, it's too easy to get lost and/or be hurt and far away from civilzation.
2 Take a water filter with you. The terrain will make you drink tons of water and before you know it, you'll be out of water! We filtered water out of all sorts of nasty locales, with no ill effects (Pur Voyager Series)
3 Have some sort of communication with you, just in case you have to "reach out and touch someone if you get hurt or lost". There is still no guarantee that you'll get enough reception, but bring the phone/radios along just in case.
4 Wear the right shoes. I didn't invest in good hiking boots and my feet and ankles were raw! I now have a $300 pair of boots and my feet are just fine!
5 Pack light, but keep the essentials (sleeping bag, fire starting equip, tent, compass, first aid stuffs, food, small flash light, knife and personal hygene products).
6 Hang your food HIGH in a tree and over a ravine, if possible. We had a black bear come into our camp twice the same evening, trying to get to our food. Bears and in some areas, wild pigs are a real risk to hikers(per the Rangers that we spoke with).
7 We climbed alot of rough terrain and risked, falling off the damn mountain. There are plenty of places to fall to your death, so pick your trail and / or path wisely.
... as cool as hiking the Appalician Trail is, it isn't a bike trail, near any sort of thriving city,so BE CAREFUL!