Glocks are essentially "revolvers" with magazines since every pull of the trigger produces a bang (assuming no misfires). There is no safety (the "safe" trigger does not count) other than keeping your finger out of the trigger guard and making sure you have a 9 lb. NYPD trigger. I personally like Glocks. Easy to shoot. Accurate. But bear in mind they are not as safe as a 1911 (even in Condition 1). Get at least a .40, and preferably a .45.
I have to agree with folks that the H&K USPs are nice. One of my friends who is a Federal judge carries one in .40 cal. Given a choice, I would go with a .45.
My preferred night-time sidearm is a SIG P220 with a Surefire Nitrolon Weaponlight, since having an integral light makes target identification much easier. I also have it fitted with a Crimson Trace Corporation Lasergrip, which places the dot in the middle of the lighted area. It's a bulky package, for which there are no concealment holsters, but for a home defense gun, it's hard to beat. It also takes extended 10 round magazines made by Promag, which seem to be as reliable in my experience as the factory 7 and 8 round magazines.
I have a Springfield Armory V10 Ultracompact, but since it is ported, it is completely unsuitable for nighttime shooting. It is strictly a daytime gun.
I personally have always liked Smiths in .45 ACP, even with the slide-mounted safety (not a decocker). Some folks don't, but they really are nice guns. Smith is now making a 1911-style .45, so if you prefer that type of firearm, they make an excellent one.
In these heavier calibers, especially for home defense at close range, +P ammo is literally "overkill" (as in overpenetration danger).
My back-up gun is a Smith Model 39, but since it's only a 9mm, I would not consider it a primary side-arm. Ditto my Smith Centennial on .38 Spec.