This is like my 5th or 6th year to visit Columbus for a convention. I'm familiar with the airport, but I've never driven in and carried a firearm there. Your airport is pretty small compared to DFW, so it's not hard to find your way around.
Seems like downtown Columbus is getting better. The first time I went, I stayed at a hotel off 70 near Buffalo Wild Wings and was told it was an easy walk to the convention center. BS, that was a trek, and once you got away from the convention center, everything was boarded up except for jewelry stores selling "grills". Next year I stayed at the Marriott, which was better except it was a block over from the YMCA and people would beg for money so they could spend the night.
After that, I got my shit together and got rooms at one of the hotels connected to the convention center, don't venture out much except to go to the market and a few places around the arena. Of course if I can find a cabbie who isn't batshit crazy, we'll make a trip to Schmidts.