If you like Glocks, then one of those should work fine for what you want.
If not, a Sig P220 would be a good choice. Great reliability and accuracy.
I had an HK USP/45F once, and it worked great. I preferred the P220's grip, so I stayed with the Sig and sold the HK. The HK performed fine though.
I have an EAA Witness, which is 10rds, and so far has been 100%, but I haven't shot it enough to recommend it for defense. It is a VERY accurate gun. I was quite suprised at how accurate. It has a VERY comfortable grip as well.
I've never had a problem with my Colt GM enhanced.
If you don't mind six rounds, it doesn't get much more reliable than a S&W .45ACP revolver.
If I were to choose from my battery of .45's, I'd have to go with the Sig P220. I've shot it the most, and it's never failed to perform. Police trade-ins are available for $379 from CDNN. They're certified by Sig, and gone through inspection and any fixing that needs to be done. I think that's probably the best bang for the buck out there in .45ACP right now.
Ross