The 22/45 has the same grip angle and feature locations of the 1911, but the safety is hard to put on/off and there are NO grip options. The most important thing in my opinion would be ergonomics and quality. I would go with the Ruger MK II over the 22/45 for the steel frame and the ability to change grips. Baretta makes a .22 target pistol that is based off the 92, but a lot smaller. I have been giving it thought myself. Although, I do not know how well it shoots. For quality .22 pistols I would recomend the following in no particular order
Smith & Wesson model 41 (My all time favorite)
Ruger MK II (A real classic)
Browning buckmark (Second favorite, but not a good choice if you enjoy gun smithing)
High Standard Victor
Marvel conversion kits for the 1911
Those pistols all come in target configurations from the factory
Others that I would not consider "target" quailty, but are still good guns are:
Walther/Smith P22
High Standard Sport King
Smith 22T (I'm not impressed with the internal quality, but it did last 5000 rds w/o breaking)
Pistols that I would avoid:
Baretta .22 tomcat (Unless he can't pull back the slide)
Baretta NEO (Simply not as accurate as I expected)
Ruger .22/45 (No grip changes. Features can be difficult to use)
All of these firearms I either own now, have in the past , or fired at least 300rds through