I have a few friends that work in the neighboring county that are issued the .40 version... and they love the gun.
So, when I was looking for a .45, I picked the PX4. Softest shooting .45 I've ever shot, and is pretty accurate. Never had any issues with it, and was completely cera-plated (Trijicons, Stealth controls, and a Bedair guide rod were also added).
Last year, I began looking for a new range gun. Wanted a Glock 34, but NJ only allows the 10 round magazines. The 9mm PX4 also has a capacity of 17 rounds, but Beretta makes a NJ compliant magazine that holds 15. Picked it up used from a member on BerettaForum, and it is at CCR for similar treatment as what was done to my .45 (only has Trijicons and an EFK extended barrel).
The only thing I don't like is that Beretta doesn't push the gun that much. The PX4 came out a year prior to the M&P, yet look at the aftermarket the M&P has compared to the PX4. There has been interest in CT to make a set of laser grips for the PX4, yet it isn't moving that far. Blackhawk putting out a Serpa for it was a nice addition, but I just don't see aftermarket companies investing time into a gun that Beretta really doesn't advertize (compared to other companies). With the Compact coming out, maybe there might be some more interest...
My biggest complaint of the platform is that Beretta has not put a .357 SIG version (just a .40 with a different barrel), and that they are not planning to put a .45 version of the Compact or S/C. I'm not getting rid of my PX4s anytime soon, but I don't see myself buying another Beretta pistol unless they put out something smaller in .45.