OP, depending on the particulars of "down the road", I'd check about getting the 101 back. Have your wife handle/shoot a full size revolver sure, but, if the weight is too much, or depending on her hand size, the size is too big to comfortably handle, you made need the 101 again. My wife can't easily handle any revolver larger than my SP101. If yours is adverse to recoil, the smaller & lighter J-frame Smiths are a no-go.
The 101 is a good balance between size and heft. Yeah,full-power .357 loads can be stout, but all .38spc loads are, IMO, tame in it. I typically carry Buffalo Bore's .38 +P 158gr SWCHP in mine and it is one of the hottest .38 loads you will find and it's much milder than .357. The first time I shot a regular .38 wadcutter round in the 101, I honestly thought I'd had a squib it was so mild. If .38's in a 101 are too much for you wife to shoot, she's likely to have a hard time finding a handgun she will be ok with. No offense to her.
Good luck