I see that people continue to diss the Glaser Safety Slug.
Let me tell you about my personal experience with the Glaser Safety Slug.
Back when the Charter Arms Bulldog was the hot CCW wheelgun rig, I had one of the nice stainless steel versions, with the spurless hammer, and the well shaped, long, but slender synthetic stocks. The 80s were the age of innocence, possibly even the age of ignorance. I bought a 6 pack of Glaser Safety Slugs.
It took a few weeks after work, but the family had a barn out back, dating from the horse and buggy era. Groundhogs abounded in the field next to it, but were difficult to approach. They never expected an ambush from the barn however.
One spring afternoon, I peered through a knot hole, and not 15 yards away I saw that familiar profile. I shot around the corner and made one quick double action shot. Yes, the groundhog fell DRT! (Not that I was familiar with that acronym at that time).
It made a very large entrance wound, but didn't penetrate. I decided my .38 Super was probably the better performer, (125 grain Silvertips were available at that time).
Of course, I also remember that groundhog that I shot with a .357 Mag Keith load. He jumped up in the air and spun around a couple of times, but hit the ground running and got into his hole. Excessive expansion works on groundhogs better than excessive penetration.
For anything larger than groundhogs, I would look for some thing besides the Glaser Safety Slug, though it does work well on groundhogs.