Yep...hormone therapy will be absolutely necessary...and it can take some time to find the right "cocktail". Every woman is different, so your input is actually pretty important. You know what she is "supposed to be like". If she starts acting "weird" it'll be important for you to say something so she can get with her physician and change her meds. With the wrong meds she can become extremely moody, depressed (even dangerously so), and just plain "wrong". This would not be a good time to "keep your opinion to yourself". I think most women deal with it fine, with just a little moodiness until they get used to it. But some react weirdly. I had a friend who became suicidal––-but that's worst case scenario.
I suppose it's like postpartum depression. Not all women get it. Some go nuts.
Mister Hystersisters - info. for the guys - they also offer a support forum for her and an e-book for you
The Hysterectomy Association (forum)
I had one when I gave birth to my son...but not total...so I don't have the hormone issues...The healing time was the biggest problem...and the loss of libido. The husband and I were both pretty terrified that I wouldn't get that back...but my mom (who also had one) assured me that it would return. It took nearly 6 months before I actually wanted to have sex. And at least that long for sex to stop hurting (but I also had a pretty traumatic birth). I actually cried during sex the first few months after (big turn off), even once I'd healed. It actually decreased my length (internally) - maybe that's normal. It was pretty scary, especially since we were newly married and terrified that our sex life might be coming to a crashing halt.
We had lots of arguments because I felt guilty and pissed off about the whole thing and he was understandably concerned about his future sex life. Plus, I was probably still a little wonky after the birth and dealing with the emotional upheaval caused by not being able to have more kids .
After nearly a year, the planets were completely re-aligned. I do still occasionally feel pain if he goes "too deep". But that can be dealt with easily with a quick verbal que.
All I can say is, be patient, but assert your needs as well. She could be fine...but she could also be a wreck. Just be ready to support her. Talk, talk, talk your way through it.
Good luck!