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Posted: 8/10/2011 5:46:14 PM EDT
http://www.msnbc.msn.com/id/44090512/ns/health-cancer/#.TkMyq2uf5pg



In the research published Wednesday, doctors at the University of Pennsylvania say the treatment made the most common type of leukemia completely disappear in two of the patients and reduced it by 70 percent in the third. In each of the patients as much as five pounds of cancerous tissue completely melted away in a few weeks, and a year later it is still gone.



In the Penn experiment, the researchers removed certain types of white blood cells that the body uses to fight disease from the patients. Using a modified, harmless version of HIV, the virus that causes AIDS, they inserted a series of genes into the white blood cells.  These were designed to make to cells target and kill the cancer cells.  After growing a large batch of the genetically engineered white blood cells, the doctors injected them back into the patients.



In similar past experimental treatments for several types of cancer the re-injected white cells killed a few cancer cells and then died out. But the Penn researchers inserted a gene that made the white blood cells multiply by a thousand fold inside the body. The result, as researcher June put it, is that the white blood cells became "serial killers” relentlessly tracking down and killing the cancer cells in the blood, bone marrow and lymph tissue.
Link Posted: 8/10/2011 5:49:17 PM EDT
[#1]
Intradasting
Link Posted: 8/10/2011 5:49:31 PM EDT
[#2]
Nanoprobes.  It has begun.
Link Posted: 8/10/2011 5:50:39 PM EDT
[#3]
Link Posted: 8/10/2011 5:50:54 PM EDT
[#4]

Fuck yeah, science.







Link Posted: 8/10/2011 5:52:53 PM EDT
[#5]
Amazing if true, but sad for those we've lost already...
Link Posted: 8/10/2011 5:53:33 PM EDT
[#6]
I hope they finally found a way to kill cancer once and for all!
Link Posted: 8/10/2011 5:54:04 PM EDT
[#7]
Cloud. Silver Lining. America. Fuck yeah!
Link Posted: 8/10/2011 5:54:47 PM EDT
[#8]
I Am Legend.
Link Posted: 8/10/2011 5:54:47 PM EDT
[#9]
Link Posted: 8/10/2011 5:55:20 PM EDT
[#10]
I thought stem cell were the answer to all our medical problems.

Great job there.
Link Posted: 8/10/2011 5:55:33 PM EDT
[#11]
Quoted:
I hope they finally found a way to kill cancer once and for all!


This
Link Posted: 8/10/2011 5:56:49 PM EDT
[#12]
Link Posted: 8/10/2011 5:57:26 PM EDT
[#13]
Well look at that shit.

Ironically, HIV might eventually save more lives than it takes.

Can't really say that I saw that one coming a few years ago.
Link Posted: 8/10/2011 5:58:33 PM EDT
[#14]
Quoted:
Quoted:
Amazing if true, but sad for those we've lost already...


My sister died from leukemia, so I won't be sad if that damned disease is eliminated. She is gone and nothing will bring her back, but maybe soon no one else will die from it.


Agreed.  Lost one of my best friends in '08.  He was 28.
Link Posted: 8/10/2011 5:59:12 PM EDT
[#15]
That's pretty damn cool
Link Posted: 8/10/2011 5:59:59 PM EDT
[#16]
Quoted:
I Am Legend.


My thoughts exactly......
Link Posted: 8/10/2011 6:00:07 PM EDT
[#17]
Hmmm... I actually have OP on my ignore list, but I couldn't resist dropping in here to mention that this is exactly how the zombie apocalypse begins.
Link Posted: 8/10/2011 6:01:15 PM EDT
[#18]
Pretty awesome.    



This has applications,  ya think?
Expect many variations on the theme, including modified white blood cells that destroy your excess fat cells,  and can be stopped

when your weight loss is complete by taking a drug that tells the modified cells to self-destruct.





CJ


Link Posted: 8/10/2011 6:02:46 PM EDT
[#19]


My nephew got leukemia when he was 4. It's been in remission for a long time now, but I fuckin' hate that disease.

Link Posted: 8/10/2011 6:03:38 PM EDT
[#20]
Was published in tomorrow's NEJM. If anyone has any questions let me know.
Link Posted: 8/10/2011 6:04:24 PM EDT
[#21]
Quoted:
Quoted:
I Am Legend.


My thoughts exactly......


Yep
Link Posted: 8/10/2011 6:04:56 PM EDT
[#22]
Quoted:
Was published in tomorrow's NEJM. If anyone has any questions let me know.


Is it only good for leukemia or will it be adaptable to other types of cancer as well?
Link Posted: 8/10/2011 6:05:50 PM EDT
[#23]
Science is crazy cool.

People that come up with this stuff are amazingly smart!
Link Posted: 8/10/2011 6:06:36 PM EDT
[#24]
That is outstanding.  My dad got really lucky with something similar to this years ago.  He had malignant melanoma that had metastasized, and things did not look good.  He was picked for an experimental vaccine being tried for skin cancer, and it worked.
Link Posted: 8/10/2011 6:06:44 PM EDT
[#25]
Quoted:
Was published in tomorrow's NEJM. If anyone has any questions let me know.


How many years before it's likely to go commercial?


Link Posted: 8/10/2011 6:09:02 PM EDT
[#26]
who would have though HIV saving the day ?
Link Posted: 8/10/2011 6:09:08 PM EDT
[#27]
Unpossible! Science is a religion and we all know how all those scientists lied about Global warming! so this is a lie too!

Link Posted: 8/10/2011 6:14:47 PM EDT
[#28]
five lbs of cancerous tissue melted away?



Maybe someone could load up the Congressional Q-Tip containers with some of those magic white cells?
Link Posted: 8/10/2011 6:16:59 PM EDT
[#29]



Quoted:



Quoted:

I Am Legend.




My thoughts exactly......
That or...









 
Link Posted: 8/10/2011 6:18:14 PM EDT
[#30]



Quoted:



Quoted:

Amazing if true, but sad for those we've lost already...




My sister died from leukemia, so I won't be sad if that damned disease is eliminated. She is gone and nothing will bring her back, but maybe soon no one else will die from it.


This. Except it was my best friend and Father of 4.



 
Link Posted: 8/10/2011 6:18:59 PM EDT
[#31]
Quoted:
Quoted:
Was published in tomorrow's NEJM. If anyone has any questions let me know.


Is it only good for leukemia or will it be adaptable to other types of cancer as well?


Ok I finished reading the article.  Your question is hard to answer at this time.  Essentially it boils down to attacking tumor cells which express certain molecules on their surface.   Solid tumors could be targeted, but if they mutated and stopped expressing the target on their surface, the therapy would stop working.  That is to say, the mutant subclone lacking the surface antigen would proliferate as its neighbors continued to die, eventually taking over such that 100% of the tumor mass comes from the mutant subclone, against which the T-cell therapy discussed is ineffective.

I think it's very exciting, though.  Stuff like this has been tried for years but this is the first really successful result.


eta: We don't even know that this will work in other Leukemias, yet.  In fact, there are some undesirable side-effects (marked or absolute B-lymphopenia and hypogammaglobulinemia) which persist, the long-term effect of which is unknown.
Link Posted: 8/10/2011 6:20:05 PM EDT
[#32]
What could possibly go wrong?
Link Posted: 8/10/2011 6:20:23 PM EDT
[#33]
Quoted:
Quoted:
I Am Legend.


My thoughts exactly......


Lol that is exactly what I thought!
Link Posted: 8/10/2011 6:20:30 PM EDT
[#34]
That is cool
Link Posted: 8/10/2011 6:20:45 PM EDT
[#35]
Fuck cancer.
Link Posted: 8/10/2011 6:23:50 PM EDT
[#36]


Sure, lets take the genes from HIV put it into some white blood cells, then lets add a gene that causes the white blood cells to divide a few thousand fold and inject it into someone with cancer. What could possibly go wrong? This is how zombie apocalypses start gentlemen.





Don't get me wrong, it will be great if it works but if you can't see the potential risks you should be messing with this stuff.




Edit: What I want to know is, what are the HIV genes are doing that the white blood cells can't do on their own and why aren't the white blood cells killing everything in it's path while diving uncontrollably?
Link Posted: 8/10/2011 6:24:26 PM EDT
[#37]
We can all go back to bareback buttsex
Link Posted: 8/10/2011 6:25:19 PM EDT
[#38]
Quoted:
We can all go back to bareback buttsex


I think you need to re-read the summary.
Link Posted: 8/10/2011 6:28:22 PM EDT
[#39]
Awesome.



I know a couple of people fighting leukemia right now.
Link Posted: 8/10/2011 6:28:45 PM EDT
[#40]
Wait, no mention of magnets? That article is all bullshit!
Link Posted: 8/10/2011 6:29:05 PM EDT
[#41]



Quoted:



Quoted:

We can all go back to bareback buttsex




I think you need to re-read the summary.







 
Link Posted: 8/10/2011 6:32:47 PM EDT
[#42]

So, when the evil, white, capitalist pigs invented the AIDS virus and infected half of Africa, it was really just means to an end to cure cancer?
Good to know.
Link Posted: 8/10/2011 6:33:13 PM EDT
[#43]
Modifying one nasty disease to kill another.
Link Posted: 8/10/2011 6:34:03 PM EDT
[#44]
Cool. Until we can make mechanical microbots/nanobots, biological things will do a fine job. Defeating cancer is a very large step towards immortality being available.
Link Posted: 8/10/2011 6:35:56 PM EDT
[#45]
Quoted:
Quoted:
We can all go back to bareback buttsex


I think you need to re-read the summary.



Too late. He's already grabbed his towel and is headed for the bathhouse.


Link Posted: 8/10/2011 6:36:13 PM EDT
[#46]
Side effects may include speech slurring, decreased motor control, and insatiable hunger for brains.
Link Posted: 8/10/2011 6:37:59 PM EDT
[#47]
Quoted:
Modifying one nasty disease to kill another.


I think they call it ingenuity.

Link Posted: 8/10/2011 6:42:25 PM EDT
[#48]



Quoted:




I thought stem cell were the answer to all our medical problems.







Stem cells when you don't have enough tissue.



This is when you have too much.



 
Link Posted: 8/10/2011 6:44:52 PM EDT
[#49]



Quoted:



Quoted:

I Am Legend.




My thoughts exactly......


Same here. This is what caused the zombie outbreak.

 
Link Posted: 8/10/2011 6:45:02 PM EDT
[#50]
Nothing could possibly go wrong with injecting people with AIDS.

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