Found the specific subsection dealing with a private residence and they still manage to make it confusing.
Title 11, Part 1, Chapter 5, Subchapter 7, Section 1457, Subsection (g) states:
"It is an affirmative defense to prosecution for a violation of this section that the prohibited conduct took place entirely within a private residence, and that no person under the age of 18 was present in such private residence at any time during the commission of the offense. The affirmative defense established in this section shall be proved by the defendant by a preponderance of the evidence. Nothing herein shall be construed to establish an affirmative defense with respect to a prosecution for an offense defined in any other section of this chapter."
So it seems that in DE, if you live within 1000ft of a Safe School & Recreation Zone you are not screwed entirely....however, the defense seems to be limited by the fact that no person under the age of 18 was present at the time. There is rarely someone under 18 at my house, but I can see how this could cause problems for homeowners with children or family under 18.