Remember the fact that the weight rating on the tire is determined at the MAX inflation pressure. Running it even 10% low will reduce the weight rating by at least 10%, 20% under inflated drops weight rating by around 25-30%...for a max inflation rating of 35 PSI, 10% means only 3.5 pounds under or 31.5 psi... For those running 10 psi low on a 35psi tire, you should realize that you've probably lost about 40% of your weight capacity and are probably in the negative region...thus even with the vehicle totally unloaded, you're riding on overloaded tires. (of course if it's an 80 psi rated tire, you've only lost maybe 15% of your weight capacity
)
Do what ya gotta to keep the tread wear even, but if you're carrying a heavy load, pump the tire up to full rating.
The above numbers come from some research I did for a presentation and in part are based on NHTSB studies.
On my truck, I run the max pressure for my LTX's and have seen NO funny treadwear patterns, but I keep a good watch on them just the same, this is over the last 50K miles BTW
Oh yeah, use a quality tire guage. I've had some frightening results from the .99C specials...as in having one tire that was 20 psi OVER rating
and another one on the same truck that was 10 psi UNDER...scared me enough to buy a decent guage.
The book answer to your question is to always go by the lable on the door if you're using OEM tires, however, you'll always be safe using the tire rated pressure. The numbers on the door are generally there for best ride and even the owners manuals will tell ya to adjust for heavier loads usually.